Review Article
GSK-3: A Bifunctional Role in Cell Death Pathways
Table 4
Selected list of known GSK-3β inhibitors.
| Inhibitor | Inhibition potency | Mode of inhibition | Notes |
| Beryllium | IC50 = 6 mM | Mg competitor | Also inhibits cdc2 | Lithium | Ki =2 mM | Mg competitor | | Anilino maleimides (SB216763, SB415286) | Ki = 10–30 nM | ATP competitor | Does not inhibit a range of other kinases | Arylpyrazolopyridazines (e.g., 6-aryl pyrazole [3,4-b] pyridine 4) | IC50 = 0.8–150 nM | ATP competitor | Also inhibits CDK2 | Bisindole maleimides (e.g., Ro 31-8220, GF 109203x) | IC50 = 5–170 nM | ATP competitor | Also inhibits PKC | Indirubins (6-bromoindirubin-3′-oxime, aka BIO) | IC50 = 5–50 nM | ATP competitor | Also inhibits CDKs | Paullones (alsterpaullone) | IC50 = 4–80 nM | ATP competitor | Also inhibits CDKs | Pseudosubstrate peptide | Ki = 0.7 mM | Substrate competitor | Specific |
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