The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function

Figure 2

LPL folds into a compact structure that bundles actin filaments. Numbers indicate each CH domain. Based on available experimental data, it has been proposed that ABD2 binds to a polymerizing actin filament such that the nucleotide-binding cleft adopts a more “closed” position, thus stabilizing the filament. Binding of ABD1 to an adjacent filament cross-links F-actin into tight bundles.