The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function

Table 1

The kinases that regulate phosphorylation of LPL in response to various cell stimuli are listed, along with the inhibitor used to test the participation of each kinase. The kinases that phosphorylate LPL in other cell types, such as T cells and macrophages, have not yet been defined. References are numbered according to appearance in the text.

Cell Type	Receptor	Ligand	Inhibitor	Kinase inhibited	Ref.
Neutrophils	FcγR	IC	H89; Wortmannin	PKA; PI3K	[49]
Neutrophils	FPR (high affinity)	fMLP	Ro-31-8220	PKC	[39]
Neutrophils	FPR-L1 (low affinity)	fMLP	LY294002; butanol; Ro-31-8220	PI3K; PLD; PKC	[39]
Eosinophils	GMR	GM-CSF	siRNA	PKCβII	[60]

Abbreviations: FcγR: receptor for the Fc portion of immunoglobulin; IC: immune complexes; fMLP: N-formyl-L-methionyl-L-leucyl-L-phenylalanine; PKA: protein kinase A; PI3K: phosphatidylinositol 3-kinase; PKC: protein kinase C; FPR: formyl peptide receptor; FPR-L1: formyl peptide receptor-like 1; PLD: phospholipase D; GM-CSF: granulocyte macrophage colony stimulating factor; GMR: GM-CSF receptor.