Actin Dynamics Associated with Focal Adhesions

Figure 2

Domain organization of proteins involved in the regulation of actin assembly in focal adhesions. ABD, actin-binding domain; FERM, four-point-one, ezrin, radixin, moesin; IBD, integrin binding domain; VBS, vinculin-binding site (11 VBSs are indicated as red vertical bars); GBD, G-binding domain; DID, diaphanous inhibitory domain; DD, dimerization domain; FH1, formin homology domain 1; FH2, formin homology domain 2; DAD, diaphanous autoregulatory domain; CH, calponin homology; SP, spectrin repeat; EF, EF hand motif; EVH1, Ena/VASP homology domain 1; EVH2, Ena/VASP homology domain 2.