Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases
Schema of synaptic biology relating to Alzheimer’s disease. APP is present in endosomes, including early and late/MVB endosomes, as well as at the cell surface. A is associated with MVBs and other endosomes, as well as being secreted from the cell surface, also via exosomes. The relative proportions of A peptides and APP processing in the pre- versus postsynapse remain uncertain. The cellular mechanism(s) of A transmission from or to the pre- and postsynapse is also not yet clear. MVB: multivesicular body; EE: early endosome; SV: synaptic vesicle.