Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases

Figure 1

Pathogenic mutations and polymorphisms in the human PrP. The pathogenic mutations associated with human prion diseases are shown above the human PrP coding sequence. These consist of 1, 2, or 4–9 octapeptide repeat insertions (OPR1-9) within the octapeptide repeat region between codons 51 and 91, a 2 octapeptide repeat deletion (OPR2), and various point mutations causing missense or stop amino-acid substitutions. Point mutations are designated by the wild-type amino acid preceding the codon number, followed by the mutant residue, using single letter amino-acid nomenclature. Polymorphic variants are shown below the PrP coding sequence.