PKM2, a Central Point of Regulation in Cancer Metabolism

Figure 3

Diagram showing the nuclear function of PKM2. PKM2 dimers in the nucleus bind to Oct 4 and HIF-1α and enhance their transcription activity; EGFR signal activates Src tyrosine kinase, which phosphorylates β-catenin at tyrosine (Y) 333 (P-Y333). PKM2 binds Y333-phosphorylated β-catenin, contributing to β-catenin-mediated transcription of cyclin D and c-Myc; PKM2 dimer possesses kinase activity that phosphorylates Stat 3 at Y705, which enhances Stat 3’s transcriptional activity.