Modulation of Vascular Cell Function by Bim Expression
Figure 8
Bim−/− pericytes diminished capillary morphogenesis of retinal endothelial cells. Wild-type (WT) and Bim−/− retinal endothelial cells (REC) were plated alone or with wild-type or Bim−/− pericytes (PC) in Matrigel and photographed in digital format (panel (a)). The quantitative assessment of the data is shown in panels (b) and (c). In panel (d), wild-type retinal endothelial cells were plated alone or with Bim−/− pericytes in the presence or absence of sFlt1 or IgG control (10 g/mL) and photographed. Panel (e) is the quantitative assessment of the data in panel (d). The data are the mean number of branch points per field (×40) ± SD. These experiments were repeated at least twice with similar results (***; ****).
