Disulfide Bonding in Neurodegenerative Misfolding Diseases

Table 1

Presence of disulfide bonds in proteins involved in neurodegenerative misfolding diseases.

Neurodegenerative disease	Protein	Cellular localization	Localization of deposits	Presence of SS
Prion-related disorders	Prion	Membrane-bound	Extra- and intracellular	Yes
Amyotrophic lateral sclerosis	SOD1	Cytosol	Intracellular	Yes
	TDP-43	Cytosol/nucleus	Intracellular	No
	FUS	Cytosol/nucleus	Intracellular	No
Alzheimer’s disease (Tauopathies)	Aβ	Extracellular	Extracellular	No
	Tau	Cytosol	Intracellular	Yes
Parkinson’s disease	Synuclein	Cytosolic, membrane-bound	Intracellular	No
	Synphilin-1	Cytoplasm	Intracellular	No
Huntington’s disease	HTT	Cytosol	Intracellular	No
Spinal and bulbar muscular atrophy X-linked 1	Androgen receptor	Cytosol/nucleus	Intracellular	No
Spinocerebellar ataxias	Ataxins	Cytosol/nucleus	Intracellular	No