Aberrant Alternative Splicing Is Another Hallmark of Cancer

Figure 1

The original six hallmarks of cancer were proposed by Hanahan and Weinberg in 2000. Eleven years later, their list had grown to ten; but it could conceivably grow even further. An additional hallmark could be aberrant alternative splicing, in which the regulation of alternative splicing has gone astray systematically causing the inappropriate expression of multiple oncogenic splice isoforms.