Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox
Figure 1
Caenorhabditis elegans alternative splicing events. (a) Genome-wide analysis of alternative splicing in C. elegans; (b) comparison of the human APAF1 and the C. elegans homolog ced-4 gene models shows significant differences in intron size between species for genes with important alternative splicing events; (c) Y48C3A.5 intron 4 (19,927 bp) is one example of the 144 introns in the C. elegans genome that are more than 10 kb in length; (d) C. elegans unc-52 gene undergoes complex alternative splicing that generates at least 12 different isoforms by the use of nine different cassette exons.
