Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
Figure 5
PK profile of OST577-IgG1 WT and mutant Abs following intravenous injection to rhesus monkeys. The concentration of OST577-IgG1 Abs in rhesus serum was measured in a validated ELISA using the mouse anti-OST577 anti-Id mAb for capture and the HRP-conjugated goat anti-human λ L chain Ab for detection (adapted and modified from Figure 2, [99]).
