The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration

Figure 1

Domains of PDIA1. TRX-like domains representing catalytic active domains a a′. The b domain and b′ are catalytically inactive. The linker region is responsible for binding to the substrate. The C terminal is followed by an ER retrieval signal KDEL.