International Journal of Cell Biology / 2013 / Article / Fig 2

Review Article

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases

Figure 2

Schematic representation of two possible mechanisms of de novo propagation of prions from recPrP fibrils. (a) In this model, the preparation of recPrP fibrils contains very small amounts of classical . A long incubation time is required to amplify and propagate in vivo this minute amount of . (b) The second model (“deformed templating" mechanism) hypothesizes that there is no classical in the fibril preparation and that recPrP fibrils can be converted into PrPres ( -like structures) with low efficiency. After several passages, these -like structures progressively adopt the structural features of classical . Schema adapted from Makarava et al., 2011 [48].

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.