International Journal of Cell Biology / 2013 / Article / Fig 2

Review Article

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases

Figure 2

Schematic representation of two possible mechanisms of de novo propagation of prions from recPrP fibrils. (a) In this model, the preparation of recPrP fibrils contains very small amounts of classical . A long incubation time is required to amplify and propagate in vivo this minute amount of . (b) The second model (“deformed templating" mechanism) hypothesizes that there is no classical in the fibril preparation and that recPrP fibrils can be converted into PrPres ( -like structures) with low efficiency. After several passages, these -like structures progressively adopt the structural features of classical . Schema adapted from Makarava et al., 2011 [48].
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(a)
975832.fig.002b
(b)

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