International Journal of Cell Biology / 2013 / Article / Tab 1

Review Article

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases

Table 1

Prion model of induction described for neurodegenerative diseases.

DiseaseNormally folded protein
Abnormally folded protein
“Prion form”
Protein aggregates detectedSeeding inoculumPrion-like propagation in mammalsReferences

CJD/scrapiePrPCPrPScPrPSc deposits plaquesVarious mammalian prions and recPrP fibrilsWT and Tg mice
Non-human primates
[32, 33, 3740]

Alzheimer (AD)Amyloid precursor protein (APP)Amyloid beta peptides A Aβ plaquesHuman AD and Tg mice brain extracts

TauopathiesTauTau aggregatesNeurofibrillary tangles (NFTs)Tg(HuTauP301S) brain extractsTg(wt Tau)[59, 60]

Parkinson (PD)α-Synucleinα-Synuclein aggregatesLewy bodiesHuman
α-Syn fibrils
(i) Fetal tissue grafts in human PD patients[61, 62]
(ii) Tg (α-SynA53T) and WT mice[63, 64]

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.