Schematic representation of the current understanding of p38δ MAPK signalling and activation. A variety of extracellular stimuli can activate the MAPK signalling pathway resulting in dual phosphorylation of p38δ MAPK. Known substrates of active p38δ MAPK include transcription factors, structural proteins, kinases, and translation repressors. Phosphorylated substrates affect several cellular processes and contribute to the pathogenesis of diseases such as cancer, diabetes, and neurodegenerative and inflammatory conditions.
