International Journal of Cell Biology / 2014 / Article / Tab 1

Review Article

p38δ MAPK: Emerging Roles of a Neglected Isoform

Table 1

Known p38δ MAPK substrates and their biochemical functions.

SubstrateFunctionConsequences of phosphorylation

AP1Transcription factorActivation of transcription, involucrin expression, keratinocyte differentiation [58]
ATF2Transcription factorActivation of transcription [7, 9]
C/EBPTranscription factorKeratinocyte differentiation [59]
c-mybTranscription factorc-myb degradation [109]
eEF2KInhibitory kinaseeEF2 activation, protein synthesis [53]
Elk1Transcription factorActivation of transcription [7, 9]
p53Transcription factorp21 expression, G1 phase arrest [9, 110]
PHAS-1Translation repressorDissociation from eIF4E, activation of translation [7]
PRKD1Serine-threonine kinaseInhibition of PRKD1 activity [72]
SAP-1Transcription factorActivation of transcription [9]
SAP-2Transcription factorActivation of transcription [9]
StathminMicrotubule protein Cytoskeleton reorganisation [50]
TauMicrotubule proteinMicrotubule assembly, tau self-aggregation [46]
TonEBP/OREBPTranscription factorImpaired TonEBP/OREBP transcriptional activity [41]

AP1: activator protein 1; ATF2: activating transcription factor 2; C/EBP: CCAAT (cytosine-cytosine-adenosine-adenosine-thymidine)-enhancer-binding protein; myb: myeloblastosis; eEF2K: eukaryotic elongation factor 2 kinase; eEF2: eukaryotic elongation factor 2; PHAS-1: phosphorylated heat- and acid-stable protein 1; PRKD1: protein kinase D 1; SAP: serum response factor accessory protein; eIF4E: eukaryotic translation initiation factor 4E.