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International Journal of Cell Biology
Volume 2014, Article ID 308535, 10 pages
Review Article

Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, India

Received 25 October 2013; Accepted 18 February 2014; Published 20 March 2014

Academic Editor: J. R. Davie

Copyright © 2014 Ashish Thapliyal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GTPases have been reported to prevent the aberrant cell growth and induce apoptosis in cell lines. Present review focuses on role of these two monomeric GTPases and summarizes their role in pathophysiological processes.