Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes
Figure 1
The switch regions of Ras. (a) Ras bound to GDP. This nucleotide is shown as a space-filling structure, with the magnesium ion (based on pdb file 4q21). (b) Ras bound to GppNHp (a nonhydrolysable analogue of GTP also shown as a space-filling structure). When accommodating the larger nucleotide, the switch 1 region appears to stretch and the switch 2 region swivels. (Based on pdb file 5p21. Reference: NCBI Protein Database).
