Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

Figure 3

Schematic representation of the primary structure/motifs of Dexras1 contains all four components of the guanyl nucleotide binding and hydrolysis pocket (Σ1–Σ4) arranged with an order and spacing similar to that of other G proteins. An effector loop region similar to that of Ras family members and a carboxyl terminus CAAX box site for prenylation are evident. The residues spanning from the Σ4 domain to the CAAX box comprise an extended carboxyl terminus variable domain that accounts for the greater molecular mass of hormone-responsive, basic GTP-binding proteins as compared with other Ras family proteins. Reference: Graham et al. [9].