Necroptosis: Molecular Signalling and Translational Implications
Figure 1
(a) Dimerization of caspase-8 drives apoptosis initiation without triggering necroptosis. (b) c-FlipL/caspase-8 heterodimer, by leading to reduced caspase-8 activity, can induce neither apoptosis nor necroptosis. (c) c-FlipS/caspase-8 heterodimer, by inhibiting caspase-8, leads to necroptosis induction.
