Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage

Figure 5

Nec-1 maintains blood-brain barrier integrity after ICH. Mice were administered Nec-1 or Nec-1_inactive at the time of collagenase-induced ICH. Evans blue extravasation, a sensitive measure of BBB disruption, was assessed at (a) 3 h or (b) 12 h after ICH. Data are expressed as mean ± SEM and were analyzed by one-way ANOVA followed by Student- Newman-Keuls post hoc test (^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001, 𝑛=7-8 per group).

(a)

(b)