572097.fig.003
Figure 3: 5-Lipoxygenase (5-LOX) pathway in mammalian cells. Methyl jasmonate (MJ) can inhibit this pathway at the 5-LOX level in cancer cells [47]. The multiple consequences of this effect are (1) blocking 5-lipoxygenase-mediated ROS production (lipid hydroperoxides—LOOH); (2) antiproliferative effect linked to inhibition of 5-HETE production; (3) inhibition of leukotrienes production.