Effect of Serum and Oxygen Concentration on Gene Expression and Secretion of Paracrine Factors by Mesenchymal Stem Cells

Table 3

Normalized relative expression of mRNA for paracrine factors.

	Normoxia		Hypoxia
	5%	20%	5%	20%
VEGF ()	0.535 ± 0.038^a	0.667 ± 0.067	0.725 ± 0.051^b	0.812 ± 0.085
MCP-1 ()	1.162 ± 0.145	1.410 ± 0.231	0.259 ± 0.063^b	0.557 ± 0.214^b
MIP-1α ()	0.688 ± 0.042	0.757 ± 0.051	1.196 ± 0.136^ab	1.578 ± 0.061^b
MIP-1β ()	0.690 ± 0.069	0.600 ± 0.036	0.932 ± 0.101^ab	1.290 ± 0.127^b
MMP-2 ()	0.855 ± 0.039^a	0.583 ± 0.064	0.886 ± 0.066	0.718 ± 0.135

Data reported as mean ± SE. 5% and 20% refer to the amount of serum supplement present in the media. versus 20%; versus normoxia.