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International Journal of Cell Biology
Volume 2014 (2014), Article ID 709828, 13 pages
Review Article

Formation and Regulation of Mitochondrial Membranes

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1

Received 17 September 2013; Revised 4 November 2013; Accepted 5 November 2013; Published 22 January 2014

Academic Editor: Katia Aquilano

Copyright © 2014 Laila Cigana Schenkel and Marica Bakovic. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mitochondrial membrane phospholipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. The accumulation of phospholipids within mitochondria depends on a coordinate synthesis, degradation, and trafficking of phospholipids between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. Several studies highlight the contribution of dietary fatty acids to the remodeling of phospholipids and mitochondrial membrane homeostasis. Understanding the role of phospholipids in the mitochondrial membrane and their metabolism will shed light on the molecular mechanisms involved in the regulation of mitochondrial function and in the mitochondrial-related diseases.