Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains
Figure 5
Effect of radiation on calcium-induced hepatic mitochondrial swelling. Hepatic mitochondria from C57BL/6 × BALB/c F1 hybrid mice with or without exposure to 7 Gy TBI were isolated. Calcium-induced mitochondrial permeability pore opening was tested. The response of mitochondria to calcium overload was recorded in 10-second intervals with a 540 nM spectrometer. The effect of radiation on calcium overload was found in C57BL/6 M × BALB/c F hybrid mice but not in C57BL/6 F × BALB/c M hybrid mice.
