Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery

Figure 1

Chemical modification of hyaluronan (HA) to carboxymethyl hyaluronan (CMHA). HA was chemically modified to produce CMHA in a basic solution which modifies approximately 15–20% of the 6′-OH groups of the N-acetylglucosamine residues. This process reduces the molecular weight and introduces additional carboxyl groups for stabilization of nCaP.