Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery

Figure 7

Cytotoxicity examination of CMHA, nCa, CDDP, Aq CDDP, Aq CDDP-CMHA and nCaCDDP evaluated against BT-474 and BT-47 cells using an MTS assay. (a) Evaluation of CMHA alone against BT-474 and BT-47 cells, showing no cytotoxicity. (b) Evaluation of nCa alone against BT-474 and BT-47 cells, showing no cytotoxicity. (c) Cytotoxicity evaluation using BT-474 (CD44⁻) cells. CDDP, Aq CDDP, and Aq CDDP reacted with CMHA (Aq CDDP-CMHA), and nCaCDDP curves are plotted. (d) Cytotoxicity evaluation using BT-47 (CD44⁺) cells. CDDP, Aq CDDP, and Aq CDDP reacted with CMHA (Aq CDDP-CMHA), and nCaCDDP curves are plotted.

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