Research Article
Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery
Figure 8
In vivo tumor take rate and maximum tolerable dose studies. (a) Tumor take rate study performed in athymic nude mice with 5 × 105 BT-47 cells injected subcutaneously in right rear flank of animals. Data represents average tumor volume versus days following inoculation with standard deviations. (b) Maximum tolerable dose study conducted with athymic nude mice (6–8 weeks old) carrying BT-47 tumors. An intratumoral 7 mg/kg dose of nCaCDDP (4 mice/group) was compared to an untreated control (4 mice/group). nCaCDDP caused minimal weight loss at 7 mg/kg and all animals recovered.
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