Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Figure 1

Change in body weight during DSS-induced colitis. (a) Groups of 6 or more adult mice of each indicated genotype were provided with 2.5% DSS in their drinking water for up to 10 days. Body weight measured at days 3, 5, 7, and 10 was compared to starting weight at day 0 for each mouse. The data points reflect the average change in body weight with error bars representing ±SEM. (b) Significance of day 7 weight loss of genotypes compared to the wild-type group: , , and   in Student’s unpaired -test, 95% confidence. One-way ANOVA test for the mean weight loss compared for all groups ^#.

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