Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Figure 2

Disease activity index (DAI) during DSS-induced colitis. (a) All mice were observed for outward signs of disease including weight loss, hunched posture, ruffled fur, bloody stools, and rectum prolapse. Data bars reflect the average of six or more mice per time point for each genotype with error bars set at the ±SEM. (b) DAI at day 7. Significance of day 7 weight loss of genotypes compared to the wild-type groups: and in a Mann-Whitney nonparametric unpaired -test, 95% confidence.

(a)

(b)