Research Article
Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry
Figure 1
Structures of compound A and dacomitinib, irreversible inhibitors of mutant EGFR. These compounds were dosed in PC-9 cells to test the effects of EGFR irreversible inhibitors on turnover rate of mutant EGFR.