Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

<div>Detection of various miRNA expressions in <svg height="12.9392pt" id="M42" style="vertical-align:-0.2033005pt" version="1.1" viewbox="0 -12.7359 116.684 12.9392" width="116.684pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M614 175C564 76 510 21 408 21C256 21 146 149 146 336C146 488 235 629 402 629C510 629 570 586 597 480L626 488C620 541 614 582 606 638C578 643 510 665 429 665C206 665 44 527 44 316C44 157 153 -15 402 -15C474 -15 558 5 586 11C604 45 629 119 643 165L614 175Z" id="g190-68"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="665" vert-adv-y="665"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,9.01,0)"><path d="M43 650V622C120 616 128 612 128 526V124C128 39 120 33 34 27V0H270C392 0 492 25 567 83C643 141 690 230 690 350C690 444 655 517 605 565C543 625 450 650 323 650H43ZM213 547C213 587 217 598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 529 592 439 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treated with different sizes of HA. 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452 -160 452 -59C452 39 371 59 309 59C275 59 240 58 203 58C158 58 140 77 140 96C140 110 157 129 170 138C186 135 205 133 221 133C306 133 396 185 396 293C396 328 384 360 366 381L423 378C439 387 459 413 468 429L463 437ZM219 418C277 418 314 362 314 284C314 205 275 166 231 165C176 165 137 221 137 299C137 376 177 418 219 418ZM241 -11C285 -11 314 -14 339 -24C367 -36 384 -61 384 -95C384 -157 335 -206 240 -206C166 -206 108 -165 108 -110C108 -82 128 -54 154 -32C172 -17 195 -11 241 -11Z" id="g190-104"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="468" vert-adv-y="468"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,111.819,-5.984)"><path d="M513 0V26C455 31 447 37 447 103V278C447 398 390 449 309 449C255 449 202 412 166 376V712C127 700 67 684 19 677V653C85 647 87 643 87 580V103C87 37 79 31 19 26L18 0H231V26C171 32 166 39 166 103V341C194 373 232 392 270 392C337 392 368 351 368 269V103C368 38 360 32 302 26V0H513Z" id="g190-105"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="534" vert-adv-y="534"></glyph.data></g></svg> cells following the treatment with different sizes of HA (e.g., 5 kDa-HA, 20 kDa-HA, 200 kDa-HA, 700 kDa-Ha, and no HA) and analyzing by Q-PCR as described in Section <a href="https://static.hindawi.com/articles/ijcb/volume-2015/989070/figures/#sec2">2</a>.</div>

International Journal of Cell Biology

fig4

Figure 4

Figure 4: Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer 