Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

Figure 10

HMGA1 participation in stem cell establishment. (a) DNMTs repress miR-296-5p which can no longer repress the GBM stem cell phenotype. The inhibition of DNMTs by 5-azacytidine no longer blocks miR-296-5p and stem cells are not induced. (b) HMGA1 stimulates the expression of four master pluripotent factors and, with particular efficiency, SOX2 which inhibits miR-296-5p and allows stem cell establishment. Symbols are the same as shown in Figure 1.

(a)

(b)