Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro

Table 4

qRT-PCR results of comparison among OS-induced control, OS+rhWnt3a-, and OS+rhWnt3a+rhAsp-treated AVICs.

		OS+rhWnt3a-conditioned AVICs	OS+rhWnt3a+rhAsp-conditioned AVICs
Negative regulatory molecule of bone cell differentiation	Asporin	Downregulated	Upregulated
Osteogenic marker genes	Osteopontin, Runx2	Upregulated	Downregulated
Wnt signaling-specific markers genes	β-Catenin	Upregulated	Downregulated
	Wnt3a	Upregulated	Downregulated
	Dkk1	Downregulated	Upregulated