Table of Contents
International Journal of Carbohydrate Chemistry
Volume 2013, Article ID 340546, 7 pages
http://dx.doi.org/10.1155/2013/340546
Research Article

Efficient Synthesis of Dispiropyrrolidines Linked to Sugars

Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India

Received 22 June 2013; Revised 16 September 2013; Accepted 17 September 2013

Academic Editor: J. F. Vliegenthart

Copyright © 2013 Sirisha Nallamala and Raghavachary Raghunathan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An expedient method for the synthesis of glyco-dispiropyrrolidines is reported through 1,3-dipolar cycloaddition reaction (1,3 DC reaction). The novel glycosyl dipolarophiles derived from D-glucose underwent neat [3+2] cycloaddition reaction with the azomethine ylides generated from 1,2-diketones and sarcosine to give the corresponding glycosidic heterocycles in good yields.