Table of Contents
International Journal of Carbohydrate Chemistry
Volume 2014, Article ID 941059, 8 pages
Research Article

Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators

Department of Chemistry, University of the Pacific, Stockton, CA 95211, USA

Received 4 June 2014; Revised 1 August 2014; Accepted 2 August 2014; Published 21 August 2014

Academic Editor: Francesco Nicotra

Copyright © 2014 Andrey V. Samoshin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.