Does Intensive Glucose Control Prevent Cognitive Decline in Diabetes? A Meta-Analysis

Table 2

Characteristics of included studies.

Study	Country	DM type	()	Intensive treatment ()	Conventional treatment ()	Mean (SD) age (years)		Follow-up time (months)	Female patients (%)
						Intensive	Conventional		Intensive	Conventional
Reichard et al. [13]	Sweden	1	96	44	52	29.5 ± 1.1	31.6 ± 1	50	50	48
DCCT [14]	USA/Canada	1	1441	711	730	27.1 ± 7.1	26.5 ± 7.1	60	48.5	45.9
EDIC [15]	USA/Canada	1	1144	588	556	27 ± 7	27 ± 7	144	49	45
Musen et al. [16]	USA/Canada	1	175	82	93	16 ± 2	16 ± 2	144	50	62
Naor et al. [17]	Germany	2	40	20	20	63.6 ± 5.3	63.8 ± 5.5	2	60	65
Launer et al. [18]	USA/Canada	2	2977	1469	1508	62.3 ± 5.7	62.7 ± 5.9	40	48	49
Koekkoek et al. [19]	Netherlands	2	183	97	86	59.3 ± 5.6	59.5 ± 5.3	120	42.3	35.7

All included studies were randomized controlled clinical trials (RCCT).
DCCT: Diabetes Control and Complications Trial; EDIC: Epidemiology of Diabetes Interventions and Complications Study.