Research Article
Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects
Table 1
Baseline characteristics of patients.
| | Characteristics | Total
| Subgroups | value | Low-dose group
| High-dose group
|
| | Male | 24 (72.7%) | 16 (72.7%) | 8 (72.7%) | 1 | | Age, years | 74 (68–80) | 75 (63–80) | 74 (72–80) | 0.154 | | Height, cm | 161 (155–166) | 162 (155–165) | 161 (153–166) | 0.924 | | Weight, kg | 57 (50–63) | 58 (52–64) | 52 (44–61) | 0.194 | | BMI, kg/m2 | 22 (18–25) | 22 (19–25) | 20 (17–24) | 0.154 | | Duration of DKT administration, days | 12 (7–20) | 8 (5–15) | 18 (10–24) | 0.075 | | Percentage of dietary intake eaten to fed before DKT administration, % | 60 (50–90) | 60 (50–85) | 70 (50–85) | 0.671 | | Time since last bowel movement, days | 4 (2–6) | 4 (2–6) | 5 (3–6) | 0.714 | | Concomitant drugs | | | | | | Heavy magnesium oxide | 21 (63.6%) | 14 (63.6%) | 7 (63.6%) | 1 | | Senna | 17 (51.5%) | 10 (45.5%) | 7 (36.6%) | 0.3245 | | Opioids | 4 (12.1%) | 3 (13.6%) | 1 (9.0%) | 0.7061 | | Chemotherapy | 4 (12.1%) | 2 (9.0%) | 2 (18.2%) | 0.4507 | | Complications | | | | | | Parkinson’s disease | 0 (0%) | 0 (0%) | 0 (0%) | 1 | | Cerebral vascular disease | 5 (15.2%) | 5 (22.7%) | 0 (0%) | 0.0861 | | Diabetes | 8 (24.2%) | 5 (22.7%) | 3 (27.3%) | 0.7739 | | Laboratory data | | | | | | Na (mEq/L) | 139 (136–141) | 139 (136–141) | 141 (138–142) | 0.273 | | K (mEq/L) | 4.2 (4.0–4.5) | 4.2 (3.9–4.4) | 4.4 (4.1–4.5) | 0.893 | | Cl (mEq/L) | 102 (100–105) | 103 (99–105) | 102 (101–104) | 0.863 | | AST (IU/L) | 20 (18–24) | 20 (18–24) | 20 (18–25) | 0.968 | | ALT (IU/L) | 16 (12–23) | 18 (12–26) | 14 (10–18) | 0.0874 | | T-Bil (mg/dL) | 0.6 (0.4–0.7) | 0.5 (0.4–0.8) | 0.6 (0.41–0.7) | 0.809 | | BUN (mg/dL) | 16 (14–20) | 17 (14–22) | 15 (13–16) | 0.231 | | Cre (mg/dL) | 0.8 (0.6–1.0) | 0.8 (0.6–1.0) | 0.9 (0.6–1.0) | 0.633 | | Alb (g/dL) | 3.4 (3.3–3.7) | 3.4 (3.3–3.8) | 3.4 (3.2–3.7) | 0.901 | | BS (mg/dL) | 112 (97–137) | 115 (102–137) | 109 (97–141) | 1 |
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AST, aspartate aminotransferase; ALT, alanine aminotransferase; T-Bil, total bilirubin; Cre, serum creatinine; BUN, blood urea nitrogen; Alb, albumin; BS, blood sugar; DKT, Daikenchuto.
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