Research Article
Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients
Table 6
Hardy Weinberg Equilibrium test for the control and case.
| | SNP | Malay | Chinese | Indian | | Control | Statistic | Control | Statistic | Control | Statistic | major/
major | major/
minor | minor/
minor | χ2 | p-value | df | major/
major | major/
minor | minor/
minor | χ2 | p-value | df | major/
major | major/
minor | minor/
minor | χ2 | p-value | df |
| | CONTROL | |
| CCR5
rs1799987 | GG=43
(44.8) | AG=42
(43.8) | AA=11
(11.5) | 0.023 | 0.8795 | 1 | GG=47
(49.5) | AG=41
(43.2) | AA=7
(7.4) | 0.229 | 0.6313 | 1 | GG=48
(35.3) | AG=70
(51.5) | AA=18
(13.2) | 0.916 | 0.3385 | 1 | CCL2
rs3917887 | II=32
(33.3) | DI=47
(44.0) | DD=17
(20.7) | 0.001 | 0.9745 | 1 | II=26
(27.4) | DI=57
(54.7) | DD=17
(17.9) | 2.229 | 0.1354 | 1 | II=41
(31.2) | DI=62
(51.7) | DD=17
(14.1) | 0.700 | 0.4028 | 1 | IL8
rs4073 | TT=45
(34.4) | TA=66
(50.4) | AA=14
(15.3) | 1.960 | 0.1615 | 1 | TT=35
(36.8) | TA=50
(52.6) | AA=10
(10.5) | 1.629 | 0.2018 | 1 | TT=60
(44.1) | TA=56
(41.2) | AA=20
(14.7) | 1.319 | 0.2508 | 1 | ELMO1
rs741301 | AA=82
(36.1) | AG=10 8
(47.6) | GG=37
(16.3) | 0.021 | 0.8848 | 1 | AA=42
(44.2) | AG=44
(46.3) | GG=9
(9.5) | 0.271 | 0.6027 | 1 | AA=57
(41.9) | AG=59
(43.4) | GG=20
(14.7) | 0.540 | 0.4624 | 1 |
| | CASE |
| CCR5
rs1799987 | GG=47
(35.9) | AG=69
(52.7) | AA=15
(11.5) | 1.895 | 0.1686 | 1 | GG=25
(23.1) | AG=58
(53.7) | AA=25
(23.1) | 0.5926 | 0.4414 | 1 | GG=29
(33.7) | AG=44
(51.2) | AA=13
(15.1) | 0.309 | 0.0788 | 1 | CCL2
rs3917887 | II=42
(32.1) | DI=57
(43.5) | DD=32
(24.4) | 2.036 | 0.1536 | 1 | II=20
(18.5) | DI=69
(63.9) | DD=19
(17.6) | 8.340 | 0.0039 | 1 | II=33
(38.8) | DI=40
(47.1) | DD=12
(14.1) | 0.001 | 0.9748 | 1 | IL8
rs4073 | TT=45
(34.4) | TA=66
(50.4) | AA=20
(15.3) | 0.273 | 0.0601 | 1 | TT=43
(39.8) | TA=57
(52.8) | AA=8
(7.4) | 3.477 | 0.0622 | 1 | TT=23
(26.7) | TA=51
(59.3) | AA=12
(14.0) | 3.641 | 0.0564 | 1 | ELMO1
rs741301 | AA=50
(38.2) | AG=58
(44.3) | GG=23
(17.6) | 0.741 | 0.3893 | 1 | AA=40
(37.0) | AG=51
(47.2) | GG=17
(15.7) | 0.012 | 0.9117 | 1 | AA=33
(38.4) | AG=45
(52.3) | GG=8
(9.3) | 1.761 | 0.1845 | 1 |
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p>0.05 shows consistency with HWE. Genotype data are presented as a number of subjects (%).
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