Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients

Table 7

Association of polymorphism in T2DM with and without nephropathy.

Malay

Chinese

Indian

Multiplicative model

Dominant Model

Recessive Model

Multiplicative model

Dominant Model

Recessive Model

Multiplicative model

Dominant Model

Recessive Model

Genotype; (df=2)

Allele; (df=1)

Major/; Major vs. others (df=1)

Minor/; Minor vs. others (df=1)

Genotype; (df=2)

Allele; (df=1)

Major/; Major vs. others (df=1)

Minor/; Minor vs. others (df=1)

Genotype; (df=2)

Allele; (df=1)

Major/; Major vs. others (df=1)

Minor/; Minor vs. others (df=1)

CCR5 rs1799987

2.012; 0.3656

0.955; 0.3284

1.840; 0.1749

0.0001; 0.9920

19.012; 7.4x

18.645; 1.6x

15.304; 9.2x

9.478; 0.0021

0.172; 0.9176

0.131; 0.7174

0.058; 0.8096

0.155; 0.6938

p

CCL2 rs3917887

χ2

1.545; 0.4618

6.735; 0.0094

0.041; 0.8395

1.478; 0.2241

2.460; 0.2923

0.740; 0.3897

2.259; 0.1328

0.003; 0.9563

0.511; 0.7745

0.399; 0.5276

0.468; 0.4939

0.0001; 0.9920

p

IL8

χ2

1.321

0747

1.266

0.200

0.671

1.1384

0.189

0.608

7.865

3.073

0.024

0.173

rs4073

p

0.5165

0.3874

0.2605

0.6547

0.7150

0.2859

0.6638

0.4355

0.0196

0.0796

0.8769

0.6775

ELMO1 rs741301

1.369; 0.5043

0.040; 0.8414

0.561; 0.4538

0.359; 0.5491

2.203; 0.332

1.976; 0.1598

0.011; 0.9165

1.080; 0.2986

2.282; 0.3195

0.040; 0.8414

0.274; 0.6007

1.396; 0.2374

p

<0.05 indicates an association of polymorphisms and disease in a different mode of inheritance.