Variables Associated with a Urinary MicroRNAs Excretion Profile Indicative of Renal Fibrosis in Fabry Disease Patients

Table 3

Binary logistic regression model to predict the appearance of urinary microRNAs excretion profile indicative of renal fibrosis in Fabry disease patients.

Explanatory variable (+)	Score in the model	p value
Hipohidrosis	8.571	0.003 ()
Reduced αGalA activity	7.200	0.007 ()
Angiokeratomas	6.750	0.009 ()
Male gender	4.941	0.026 ()
Neuropathic pain	4.112	0.043 ()
Hearing loss	4.000	0.046 ()
Cardiac involvement	4.000	0.046 ()
RAAS inhibitors treatment	4.000	0.046 ()
ERT	3.200	0.074
Genotype	3.553	0.059
CNS involvement	3.158	0.076
Age	2.416	0.120
GI symptoms	2.098	0.148
Pathological albuminuria	2.021	0.155

Chi squared = 0.002; Cox y Snell R² = 0.720; Nagelkerke R² = 1.000. Global percentage correctly classified = 100%.
(+) Explanatory variables with greater capacity to predict the appearance of microRNAs urinary extretion profile indicative of renal fibrosis, classified in decreasing order.
() Explanatory variables able to predict the appearance of urinary microRNAs extretion profile indicative of renal fibrosis.
References: αGalA: α-galactosidase-A; RAAS: renin-angiotensin-aldosterone system; ERT: enzyme replacement theraphy; CNS: nentral nervous system; GI: gastrointestinal.