Hippocampal Growth Factor and Myokine Cathepsin B Expression following Aerobic and Resistance Training in 3xTg-AD Mice

Figure 1

Phenotype of aerobic- and resistance-trained 3xTg-AD mice. Three-month-old 3xTg-AD mice were assigned to one of the following groups: nonexercised (Tg), aerobic trained (Tg+AT), or resistance trained (Tg+RT) (/group). Training was performed for 9 weeks, followed by tissue collection. Physical function was evaluated longitudinally, at pre- and posttraining. (a) Final body weight measured at the end of the experiment. (b) Wet weight of the gastrocnemius. (c) Association of gastrocnemius weight with grip strength. (d) Peak latency (time to fall in seconds) on the rotarod test. (e) Peak revolutions per minute (RPM) achieved on the rotarod test. (f) Average latency (time to fall in seconds) averaged across four trials on the rotarod. (g) Average forelimb grip strength across four trials. Data presented as . Differences determined by one-way ANOVA. and .

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