Table of Contents Author Guidelines Submit a Manuscript
International Journal of Chemical Engineering
Volume 2011, Article ID 267218, 7 pages
http://dx.doi.org/10.1155/2011/267218
Research Article

Uniform Chitosan Microparticles Prepared by a Novel Spray-Drying Technique

Department of Chemical Engineering, Clayton Campus, Monash University, Clayton, VIC 3800, Australia

Received 13 September 2010; Accepted 4 October 2010

Academic Editor: Jin Huang

Copyright © 2011 Wenjie Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. R. Jameela, T. V. Kumary, A. V. Lal, and A. Jayakrishnan, “Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system,” Journal of Controlled Release, vol. 52, no. 1-2, pp. 17–24, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Polk, B. Amsden, K. De Yao, T. Peng, and M. F. A. Goosen, “Controlled release of albumin from chitosan-alginate microcapsules,” Journal of Pharmaceutical Sciences, vol. 83, no. 2, pp. 178–185, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Ozbaş-Turan, J. Akbuǧa, and C. Aral, “Controlled release of interleukin-2 from chitosan microspheres,” Journal of Pharmaceutical Sciences, vol. 91, no. 5, pp. 1245–1251, 2002. View at Google Scholar · View at Scopus
  4. P. He, S. S. Davis, and L. Illum, “Chitosan microspheres prepared by spray drying,” International Journal of Pharmaceutics, vol. 187, no. 1, pp. 53–65, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. J. A. Champion, Y. K. Katare, and S. Mitragotri, “Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers,” Journal of Controlled Release, vol. 121, no. 1-2, pp. 3–9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. V. R. Shinde Patil, C. J. Campbell, Y. H. Yun, S. M. Slack, and D. J. Goetz, “Particle diameter influences adhesion under flow,” Biophysical Journal, vol. 80, no. 4, pp. 1733–1743, 2001. View at Google Scholar · View at Scopus
  7. L. Illum, S. S. Davis, and C. G. Wilson, “Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape,” International Journal of Pharmaceutics, vol. 12, no. 2-3, pp. 135–146, 1982. View at Google Scholar
  8. W. D. Wu, S. X. Q. Lin, and X. D. Chen, “Monodisperse droplets formation using glass nozzles operated with piezoelectric pulsation,” AIChE Journal. In press.
  9. W. D. Wu, R. Amelia, N. Hao et al., “Assembly of uniform photoluminescent microcomposites using a novel micro-fluidic-jet-spray-dryer,” AIChE Journal, accepted.
  10. S. A. Agnihotri, N. N. Mallikarjuna, and T. M. Aminabhavi, “Recent advances on chitosan-based micro- and nanoparticles in drug delivery,” Journal of Controlled Release, vol. 100, no. 1, pp. 5–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. L.-Y. Wang, Y.-H. Gu, Z.-G. Su, and G.-H. Ma, “Preparation and improvement of release behavior of chitosan microspheres containing insulin,” International Journal of Pharmaceutics, vol. 311, no. 1-2, pp. 187–195, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Vehring, W. R. Foss, and D. Lechuga-Ballesteros, “Particle formation in spray drying,” Journal of Aerosol Science, vol. 38, no. 7, pp. 728–746, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. A. V. Mironov, G. A. Vikhoreva, N. R. Kil'deeva, and S. A. Uspenskii, “Reasons for unstable viscous properties of chitosan solutions in acetic acid,” Polymer Science B, vol. 49, no. 1-2, pp. 15–17, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Graessley, The Entanglement Concept in Polymer Rheology, Springer, Berlin, Germany, 1974.
  15. H. K. No, S. H. Kim, S. H. Lee, N. Y. Park, and W. Prinyawiwatkul, “Stability and antibacterial activity of chitosan solutions affected by storage temperature and time,” Carbohydrate Polymers, vol. 65, no. 2, pp. 174–178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S. V. Rogozhin, A. I. Gamzazade, M. A. Chlenov, Y. Y. Leonova, A. M. Sklyar, and S. K. Dotdayev, “The partial acidic hydrolysis of chitosan,” Polymer Science U.S.S.R., vol. 30, no. 3, pp. 607–614, 1988. View at Google Scholar · View at Scopus
  17. O. V. Bobreshova, O. V. Bobylkina, P. I. Kulintsov, G. A. Bobrinskaya, V. P. Varlamov, and S. V. Nemtsev, “Conductivity of aqueous solutions of low-molecular chitosan,” Russian Journal of Electrochemistry, vol. 40, no. 7, pp. 694–697, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. R. Pereira and J. Yarwood, “ATR-FTIR spectroscopic studies of the structure and permeability of sulfonated poly(ether sulfone) membranes—part 1: interfacial water-polymer interactions,” Journal of the Chemical Society—Faraday Transactions, vol. 92, no. 15, pp. 2731–2735, 1996. View at Google Scholar · View at Scopus
  19. K. M. Vårum, M. H. Ottøy, and O. Smidsrød, “Acid hydrolysis of chitosans,” Carbohydrate Polymers, vol. 46, no. 1, pp. 89–98, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. M. R. Böhmer, R. Schroeders, J. A. M. Steenbakkers et al., “Preparation of monodisperse polymer particles and capsules by ink-jet printing,” Colloids and Surfaces A, vol. 289, no. 1–3, pp. 96–104, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. Y.-F. Maa, H. R. Costantino, P.-A. Nguyen, and C. C. Hsu, “The effect of operating and formulation variables on the morphology of spray-dried protein particles,” Pharmaceutical Development and Technology, vol. 2, no. 3, pp. 213–223, 1997. View at Google Scholar · View at Scopus
  22. D. E. Walton, “The morphology of spray-dried particles a qualitative view,” Drying Technology, vol. 18, no. 9, pp. 1943–1986, 2000. View at Google Scholar · View at Scopus
  23. N. Clarke, K. O'Connor, and Z. Ramtoola, “Influence of formulation variables on the morphology of biodegradable microparticles prepared by spray drying,” Drug Development and Industrial Pharmacy, vol. 24, no. 2, pp. 169–174, 1998. View at Google Scholar · View at Scopus
  24. P. Fäldt and B. Bergenståhl, “Fat encapsulation in spray-dried food powders,” Journal of the American Oil Chemists' Society, vol. 72, no. 2, pp. 171–176, 1995. View at Google Scholar
  25. K. Alexander and C. J. King, “Factors governing surface morphology of spray-dried amorphous substances,” Drying Technology, vol. 3, no. 3, pp. 321–348, 1985. View at Google Scholar · View at Scopus