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International Journal of Chemical Engineering
Volume 2018, Article ID 2340249, 8 pages
Research Article

Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems

Department of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, Brazil

Correspondence should be addressed to Suédina Maria de Lima Silva; rb.ude.gcfu@avlis.anideus

Received 28 October 2017; Accepted 14 December 2017; Published 22 January 2018

Academic Editor: Bhaskar Kulkarni

Copyright © 2018 Hanniman Denizard Cosme Barbosa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-FU) controlled release. Chitosan microspheres were prepared by precipitation method and the effects of manufacturing parameters (injection and airflow rates) on size distribution microspheres were analyzed by optical and scanning electron microscopy. The results show that the manufacturing parameters, injection and airflow rates, determine the microsphere size distribution. By modulating these parameters, it was possible to produce chitosan microspheres as small as 437 ± 44 μm and as large as 993 ± 18 μm. Chitosan microspheres loaded with 5-FU were also produced using the experimental equipment. The obtained microspheres presented 5-FU controlled release, indicating that the microspheres can be used orally, since they are capable of crossing the stomach barrier and of continuing with the process of 5-FU release.