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International Journal of Dentistry
Volume 2009 (2009), Article ID 143460, 6 pages
Case Report

Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature

1Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan
2Department of Oral Surgery, Nihon University Itabashi Hospital, Tokyo 173-8610, Japan
3Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

Received 11 May 2009; Revised 16 July 2009; Accepted 29 July 2009

Academic Editor: Ricardo Santiago Gomez

Copyright © 2009 Kayo Kuyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 𝛼 & 𝛽 and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.