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International Journal of Dentistry
Volume 2009 (2009), Article ID 247121, 5 pages
Clinical Study

Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients

1Department of Periodontology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey
2Department of Biochemistry, Faculty of Medicine, Karaelmas University, Zonguldak, Turkey
3Department of Oral Diagnosis and Radiology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey

Received 2 June 2009; Revised 4 July 2009; Accepted 3 August 2009

Academic Editor: Jukka H. Meurman

Copyright © 2009 Gökhan Açıkgöz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Search for hepatitis C virus (HCV) in body fluids other than blood is important when assessing possible nonparenteral routes of viral transmission. However, the role of oral fluids in HCV transmission remains controversial. Our aim was to compare the prevalence of HCV antibody (HCV Ab) levels in saliva, and gingival crevicular fluid (GCF) of HCV seropositive hemodialysis patients. Serum, saliva and GCF samples were collected from thirty-nine patients. Samples were analyzed for HCV Ab using the Ortho HCV 3.0 SAVe enzyme-linked immunosorbent assay (ELISA). HCH Ab levels in saliva and GCF of all HCV-seropositive patients were statistically compared. Reported here are the results of the study designed to determine the correlation between HCV-RNA positivity in serum and the detection of antibodies in GCF and saliva. One hundred percent (100%) of the 39 patients have antibodies to HCV in their serum, 15.4% have antibodies to HCV in GCF, and saliva found out. HCV Ab seropositivity in GCF and saliva was significantly correlated (kappa = 0.462; 𝑃 < . 0 0 1 ). This study supports the concept that GCF may be a significant source of HCV in saliva.