Reparative Dentinogenesis Induced by Mineral Trioxide Aggregate: A Review from the Biological and Physicochemical Points of View
Figure 1
Dentin bridge formation in rat molar at 14 days after direct pulp capping with MTA: H-E staining (a), immunohistochemistry of nestin (b), and osteopontin (c). (a) A thin layer of fibrous matrix (arrows) is followed by a dentin-like matrix (*) with tubular structures pulpally lined with odontoblast-like cells. (b) The odontoblast-like cells intensely express nestin, an intermediate filament expressed in differentiated odontoblasts. Their processes also show immunoreactivity for nestin in the tubular matrix (*). (c) Osteopontin immunoreactivity is detected in the superficial fibrous matrix (arrows), but not in tubular dentin-like matrix (*).
