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International Journal of Dentistry
Volume 2009, Article ID 940686, 5 pages
Case Report

Intravascular Papillary Endothelial Hyperplasia Associated with Venous Pool Arising in the Lower Lip: A Case Report

1Department of Oral and Maxillofacial Surgery, Sensory and Motor Organ Sciences, Graduate School of Medicine and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8556, Japan
2Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan

Received 6 July 2009; Revised 18 September 2009; Accepted 7 October 2009

Academic Editor: Eiichiro I. Ariji

Copyright © 2009 Hisanobu Yonezawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intravascular papillary endothelial hyperplasia is a benign nonneoplastic vascular lesion that consists of endothelial cells with abundant vascular tissue with papillary proliferation. An adult female had a painless growing dark red nodule on the left side of the lower lip and often touched and gnawed at it for more than 4 years. The lesion was a tender, smooth mass approximately 1 cm in diameter without discoloration reaction. Magnetic resonance imaging of the lesion showed specific findings. She was diagnosed clinically as having mimicked hemangioma, and the lesion was totally excised under local anesthesia. Histopathological examination revealed that papillary proliferated endothelial cells with venous pool, and the lesion was diagnosed as intravascular papillary endothelial hyperplasia associated with venous pool. There has been no recurrence for more than 1 year. Despite the benign nature of this lesion, it could have been mistaken for a malignant tumor because of its clinical course and radiologic findings.