International Journal of Dentistry / 2010 / Article / Tab 1

Review Article

A Review of the Nonsurgical Treatment of Oral Leukoplakia

Table 1

Nonsurgical treatments options for oral leukoplakia.

AuthorTherapyDoseNumber of patientsClinical resolution (%)Follow-up (months)RecurrenceMalignant transformation (%)

Benner et al. [66]Systemic Alfa tocoferol400 IU4320%24NRNR
Garewal et al. [38]Systemic Beta-carotene30 mg/day248%6NR8%
Toma et al. [37]Systemic Beta-carotene90 mg/day2326%75%NR
Sankaranarayanan et  al. [31]Systemic Beta-carotene360 mg4654%125%NR
Liede et al. [32]Systemic Beta-carotene20 mg/day24NR60–84NRNR
Garewal et al. [39]Systemic Beta-carotene60 mg/day504%1817%8%
Sankaranarayanan et  al. [31]Systemic Isotretinoin300.000 IU4252%1267%NR
Stich et al. [74]Systemic Vitamin  A200.000–300.000 IU2157%12NRNR
Nagao et al. [47]Systemic LycopeneNR48NRNRNRNR
Singh et al. [48]Systemic Lycopene4–8 mg5825-55%3NRNR
Hammersley et al. [24]Topical Bleomycin0,5%8NR12NRNR
Epstein et al. [25]Topical Bleomycin1%1932%40NR11%
Shah et al. [73]Topical Vitamin  A1–5 mg1127%1118%NR
Epstein and Gorsky [78]Topical Tretinoin0,05% gel2627%4240%NR
Piattelli et al. [72]Topical Isotretinoin1%1010%48NRNR
Lippman et al. [88]Systemic 4 HPR200 mg/day3509NR23%
Tradati et al. [87]Topical 4 HPRNR825%NRNRNR
Kübler et al. (1998)Topical PDTALA 20%2025%3NRNR
Siéron et al. [90]Topical PDTALA 10%580%620%NR
Siero et al. [96]Topical PDTALA 10%1283%68%NR
Chen et al. [97]Systemic PDTALA2433%NRNRNR

IU: International Unit; NR: not reported; 4 HPR: Fenretinide; PDT: Photodynamic therapy; ALA: Aminolevulenic acid.

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